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Bridging cord injuries
Imagine bridging a spinal cord injury with an electronic circuit. That's what this crew at the University of California are working on. Remember that the basic walking movements of the legs are mostly pre-encoded and just triggered by brain signals saying "go."
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Spinal tapped: Electrodes in this rat's front legs are routed
to a microprocessor on its back. When the processor detects
walking, it sends an electronic pulse to an electrode on
the rat’s severed spinal cord, which in turn triggers walking
in the paralyzed hind legs.
Device Helps Paralyzed Rats Walk Again
Electronic "bridge" could one day assist paralysis patients.
Until recently, severe spinal cord injuries came with a fairly definite diagnosis of paralysis, whether partial or complete. But new developments in both stem-cell therapy and electronic stimulation have begun to provide hope, however distant, that paralysis may not be a life sentence. Complicated muscle stimulation devices can enable limited standing and walking, and the first embryonic stem-cell trials began last year. Other techniques, however, may provide an even simpler solution.
In his lab at the University of California, Los Angeles, V. Reggie Edgerton is developing an electronic neural bridge, one that helps impulses jump from one side of a severed spinal cord to the other to take advantage of neural "circuitry" that remains intact even after it's been cut off from the brain. In research presented two weeks ago at the Society for Neuroscience meeting in San Diego, Edgerton and graduate student Parag Gad used this approach, combined with electromyography (EMG), to help rats with severed spinal cords and completely paralyzed hind legs to run on all fours again. When their front legs began to run, the movement triggered a small current that prompted their rear legs to keep up.
Edgerton has been working on a system that employs preëxisting abilities of the spinal cord: neural pathways that, after an injury, may be blocked but don't disappear. Although the brain may control the impulse that initiates walking, the sequential muscle-by-muscle movement is not under our conscious command. "The signal coming down from the brain isn't to activate this muscle and then this muscle and then this muscle," Edgerton says. "It's to activate a program that's built into the circuitry. A message comes down from the brain that says step. The spinal cord knows what stepping is; it just has to be told to do that."
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Spinal tapped: Electrodes in this rat's front legs are routed
to a microprocessor on its back. When the processor detects
walking, it sends an electronic pulse to an electrode on
the rat’s severed spinal cord, which in turn triggers walking
in the paralyzed hind legs.
Device Helps Paralyzed Rats Walk Again
Electronic "bridge" could one day assist paralysis patients.
Until recently, severe spinal cord injuries came with a fairly definite diagnosis of paralysis, whether partial or complete. But new developments in both stem-cell therapy and electronic stimulation have begun to provide hope, however distant, that paralysis may not be a life sentence. Complicated muscle stimulation devices can enable limited standing and walking, and the first embryonic stem-cell trials began last year. Other techniques, however, may provide an even simpler solution.
In his lab at the University of California, Los Angeles, V. Reggie Edgerton is developing an electronic neural bridge, one that helps impulses jump from one side of a severed spinal cord to the other to take advantage of neural "circuitry" that remains intact even after it's been cut off from the brain. In research presented two weeks ago at the Society for Neuroscience meeting in San Diego, Edgerton and graduate student Parag Gad used this approach, combined with electromyography (EMG), to help rats with severed spinal cords and completely paralyzed hind legs to run on all fours again. When their front legs began to run, the movement triggered a small current that prompted their rear legs to keep up.
Edgerton has been working on a system that employs preëxisting abilities of the spinal cord: neural pathways that, after an injury, may be blocked but don't disappear. Although the brain may control the impulse that initiates walking, the sequential muscle-by-muscle movement is not under our conscious command. "The signal coming down from the brain isn't to activate this muscle and then this muscle and then this muscle," Edgerton says. "It's to activate a program that's built into the circuitry. A message comes down from the brain that says step. The spinal cord knows what stepping is; it just has to be told to do that."
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