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Seems SRI's researchers got a helluva surprise....
Link....
Link....
Liver, not brain, may originate Alzheimer's
Unexpected findings from a Scripps Research Institute study could completely alter prevailing notions about Alzheimer's disease - pointing to the liver instead of the brain as the original source of the plaques that cause the disease. The findings, appearing in The Journal of Neuroscience Research, could point the way to a relatively simple approach for treating Alzheimer's.
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"The product of that gene, called Presenilin2, is part of an enzyme complex involved in the generation of pathogenic beta amyloid," Sutcliffe said. "Unexpectedly, heritable expression of Presenilin2 was found in the liver but not in the brain. Higher expression of Presenilin2 in the liver correlated with greater accumulation of beta amyloid in the brain and development of Alzheimer's-like pathology."
This finding suggested that significant concentrations of beta amyloid might originate in the liver, circulate in the blood, and enter the brain. If true, blocking production of beta amyloid in the liver should protect the brain.
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Unexpected findings from a Scripps Research Institute study could completely alter prevailing notions about Alzheimer's disease - pointing to the liver instead of the brain as the original source of the plaques that cause the disease. The findings, appearing in The Journal of Neuroscience Research, could point the way to a relatively simple approach for treating Alzheimer's.
>
"The product of that gene, called Presenilin2, is part of an enzyme complex involved in the generation of pathogenic beta amyloid," Sutcliffe said. "Unexpectedly, heritable expression of Presenilin2 was found in the liver but not in the brain. Higher expression of Presenilin2 in the liver correlated with greater accumulation of beta amyloid in the brain and development of Alzheimer's-like pathology."
This finding suggested that significant concentrations of beta amyloid might originate in the liver, circulate in the blood, and enter the brain. If true, blocking production of beta amyloid in the liver should protect the brain.
>
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